T Cell Epitope Discovery in the Context of Distinct and Unique Indigenous HLA Profiles

L Hensen; PT Illing; LC Rowntree; J Davies; A Miller; SYC Tong; JR Habel; CE van de Sandt; K Flanagan; AW Purcell; K Kedzierska; EB Clemens

Journal article

T Cell Epitope Discovery in the Context of Distinct and Unique Indigenous HLA Profiles

L Hensen, PT Illing, LC Rowntree, J Davies, A Miller, SYC Tong, JR Habel, CE van de Sandt, K Flanagan, AW Purcell, K Kedzierska, EB Clemens

Frontiers in Immunology | Published : 2022

DOI: 10.3389/fimmu.2022.812393

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Abstract

CD8+ T cells are a pivotal part of the immune response to viruses, playing a key role in disease outcome and providing long-lasting immunity to conserved pathogen epitopes. Understanding CD8+ T cell immunity in humans is complex due to CD8+ T cell restriction by highly polymorphic Human Leukocyte Antigen (HLA) proteins, requiring T cell epitopes to be defined for different HLA allotypes across different ethnicities. Here we evaluate strategies that have been developed to facilitate epitope identification and study immunogenic T cell responses. We describe an immunopeptidomics approach to sequence HLA-bound peptides presented on virus-infected cells by liquid chromatography with tandem mass s..

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University of Melbourne Researchers

Louise Rowntree Author

Steven Tong Author

Jennifer Habel Author

Carolien van de Sandt Author

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Funding Acknowledgements

LH received funding from a Melbourne International Research Scholarship (MIRS) and Melbourne International Fee Remission Scholarship (MIFRS) from The University of Melbourne. ST is a NHMRC Career Development Fellow (#1145033). JH is supported by a Melbourne Research Scholarship from the University of Melbourne. CS has received funding from the European Union's Horizon 2020 research and innovation program under the Marie Sklodowska-Curie grant agreement (#792532). KF received funding from a Clifford Craig Foundation Grant (#145). AP is supported by an NHMRC Principal Research Fellowship (#1137739) and NHMRC Project Grant (#1085018). EC is a NHMRC Peter Doherty Fellow (#1091516). KK is supported by a NHMRC Senior Research Fellowship (#1102792), NHMRC Program Grant (#1071916), NHMRC Investigator Grant (#1173871) and NHMRC Project Grant (#1122524) to KK, ST, AM, and AP.